期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 24, 页码 6952-6956出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.060
关键词
Alzheimer's disease; gamma-Secretase inhibitor; Bicyclic sulfonamides
The structural modification of a series of [3.3.1] bicyclic sulfonamide based gamma-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile. (C) 2009 Elsevier Ltd. All rights reserved.
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