期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 10, 页码 2777-2779出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.125
关键词
2-Phenylquinazolin-4(3H)-one; PDE5 Inhibitor; Selectivity versus PDE6; Sildenafil; Erectile dysfunction
资金
- National 863 Program of China [2007AA02Z145]
- Shanghai Science and Technology Development Funds [08JC1422400]
In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported. (C) 2009 Elsevier Ltd. All rights reserved.
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