期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 7, 页码 2033-2037出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.028
关键词
Artemisinin; Acridine; Antimalarial; Anticancer; Apoptosis; DNA; Confocal microscopy
资金
- BBSRC [BBS/S/P/2003/10353]
- EPSRC
- Nuffield Foundation
- Science Foundation Ireland
- National Development Plan
- Ministry of Science of Croatia [098-09829142918]
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle. (C) 2009 Elsevier Ltd. All rights reserved.
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