4.5 Article

Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 7, 页码 2440-2444

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.02.045

关键词

chromophore; fluorescence; peptides; peptide nucleic acids; ornithine; 4-aminoproline; solid-phase synthesis; antiproliferative

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The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.

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