期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 15, 页码 4438-4441出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.06.026
关键词
coactivator associated arginine; methyltransferase 1; CARM1; PRMT4; protein arginine methyltransferase
This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1. (c) 2008 Elsevier Ltd. All rights reserved.
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