期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 6, 页码 1874-1879出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.02.011
关键词
-
Rational design, synthesis, and SAR studies of a novel class of benzothiazole based inhibitors of p38 alpha MAP kinase are described. The issue of metabolic instability associated with vicinal phenyl, benzo[d] thiazol-6-yl oxazoles/imidazoles was addressed by the replacement of the central oxazole or imidazole ring with an aminopyrazole system. The proposed binding mode of this new class of p38 alpha inhibitors was confirmed by X-ray crystallographic studies of a representative inhibitor (6a) bound to the p38 alpha enzyme. (C) 2008 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据