期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 5, 页码 1559-1562出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.01.078
关键词
Anthemis maritima; cyclohexenones; cytotoxic activity; NMR; glutathione
Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC50 values ranging from 3.2 to 14 mu M. (c) 2008 Elsevier Ltd. All rights reserved.
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