期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 25, 页码 5092-5101出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00533b
关键词
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资金
- National Natural Science Foundation of China [21861162010, 22075078]
- Program of Shanghai Academic/Technology Research Leader [20XD1421400]
- Key technology research on remote screening platform of thyroid nodules and robot-assisted diagnosis between benign and malignant lesions [YG2019ZDA17]
- research program of State Key Laboratory of Bioreactor Engineering
- Fundamental Research Funds for the Central Universities [22221818014]
The study successfully synthesized antibacterial polypeptide-conjugated gold nanoparticles to combat multidrug-resistant bacteria, demonstrating potent antibacterial activity and excellent biocompatibility, implying potential applications in treating bacterial infections.
Multidrug-resistant bacterial infections are a grand challenge to global medical and health systems. Therefore, it is urgent to develop versatile antibacterial strategies that can combat bacterial resistance without displaying toxicity. Here, we synthesize antibacterial polypeptide-conjugated gold nanoparticles that exhibit potent antibacterial activities against clinically isolated multiple drug resistance Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, and excellent in vitro and in vivo biocompatibility. The antibacterial mechanism study indicates that over-production of reactive oxygen species results in the killing of bacteria. The overall antibacterial performance of these polypeptide-conjugated gold nanoparticles and the convenient synthesis of these polypeptides via lithium hexamethyldisilazide-initiated fast ring-opening polymerization on alpha-amino acid N-carboxyanhydride imply the potential application of this strategy in treating bacterial infections.
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