期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 12, 页码 3656-3660出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.04.042
关键词
IRAK; IRAK-4; IRAK-4 inhibitor; kinase; kinase inhibitor; imidazo[1,2-a] pyridine; inflammation; anti-inflammatory; ligand efficiency; IL-1; TNF-alpha; TNF alpha; immunity
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a] pyridino-pyridines and benzimidazolo-pyridines was explored. (C) 2008 Elsevier Ltd. All rights reserved.
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