期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 18, 页码 4932-4935出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.08.058
关键词
necroptosis; caspase-independent cell death; necrostatin; inhibitors; SAR; 3-aryl-pyrazole; Nec-7; thiazolidin-4-one derivatives
资金
- Chinese Academy of Sciences
- National Institute of General Medical Sciences (USA)
- National Institute of Neurological Disorders and Stroke (USA)
- National Natural Science Foundation of China [20272075, 20372076]
Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modi. cations and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis. (C) 2008 Elsevier Ltd. All rights reserved.
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