期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 17, 页码 4868-4871出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.087
关键词
antimycobacterial; antibacterial; oxazolidinone; one-pot
资金
- University of Toledo, the Ohio Science and Engineering Alliance (OSEA)
- National Science Foundation, Ohio Consortium for Undergraduate Research: Research Experiences to Enhance Learning (REEL) [CHE0532250]
C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)5-(1H-1,2,3-triazol-1-yl) methyl)-oxazolidin-2-one (18) showed an MIC of 1 mu g/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据