期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 1, 页码 391-395出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.10.031
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A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the same anti-proliferative activities as STA 21 against prostate cancer cell lines that express constitutively active STAT3. Molecular docking showed compound 1 bound to the STAT3 beta SH2 domain in a similar manner as STA 21. (C) 2007 Elsevier Ltd. All rights reserved.
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