期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 20, 页码 5439-5442出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.023
关键词
allosteric; agonist; TBPB; muscarinic receptor
资金
- NIH
- NIMH [1RO1MH082867-01]
- Vanderbilt Institute of Chemical Biology Pilot Project
- Alzheimer's Association [IIRG-07-57131]
- ITTD [T90-DA022873]
- National Research Service [1FM32 MH079678-01]
This Letter describes the first account of the synthesis and SAR, developed through an iterative analogue library approach, of analogues of the highly selective M1 allosteric agonist TBPB. With slight structural changes, mAChR selectivity was maintained, but the degree of partial M1 agonism varied considerably. (C) 2008 Elsevier Ltd. All rights reserved.
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