期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111735
关键词
Sr; Micro-arc oxidation; TiO2; Orthopedics implants
资金
- FCT [UID/EEA/04436/2019, M-ERA-NET/0001/2015]
- FCT/CAPES [4.4.1.00]
- FAPESP [2017/24300-4]
- [NORTE-08-5369-FSE-000051]
This study evaluated the effect of varying amounts of Sr in a TiO2 porous layer, with higher Sr content increasing Ca/P ratio and promoting the formation of SrTiO3 compound. Lower Sr concentrations did not affect initial cell adhesion or viability, but rather enhanced mineralization. A Ca-P-TiO2 porous layer with less Sr concentration seems to be an ideal candidate for bone implants.
One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据