期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 17, 页码 4783-4785出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.101
关键词
docetaxel analogue; synthesis; antitumor activity
资金
- NSFC [20632030, 20772083]
- Ministry of Education of China [20050610094]
Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted 10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB. (C) 2008 Elsevier Ltd. All rights reserved.
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