The Essential Factors of Establishing Patient-derived Tumor Model

Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research discoveries and to test potential therapeutic approaches. However, research in this field is hampered by the limited engraftment rate. In this review, we go over a large number of researches on patient-derived xenograft transplantation and firstly systematically summarize the main factors in methodology to successfully establish models. These results will be applied to the development of patient-derived xenograft leading to better preclinical research.

Automated summary

Establishing an applicable patient-derived xenograft model is vital for translational cancer research, but research in this field faces challenges due to limited engraftment rate. A review of numerous studies systematically summarizes key methodological factors for successful model establishment, aiming to improve preclinical research in patient-derived xenografts.