期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 8, 页码 2594-2598出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.03.039
关键词
pyrrolobenzodiazepine; benzimidazoles; in vitro cytotoxicity; DNA-binding affinity
The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines. (c) 2008 Elsevier Ltd. All rights reserved.
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