期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 15, 页码 4291-4293出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.06.100
关键词
ester aminolysis; trityl radical; oximetry; EPR; tetrathiatriarylmethyl; TAM
Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations. (c) 2008 Elsevier Ltd. All rights reserved.
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