The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

Here we identify the pharmacophore in a peptoid that antagonizes Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) in vitro and in vivo. Only three of the side chains in the peptoid are required for activity. Surprisingly, however, main chain atoms also form critical interactions with the receptor. (C) 2008 Elsevier Ltd. All rights reserved.