期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 12, 页码 3565-3569出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.05.004
关键词
anthrax
资金
- NIAID NIH HHS [U19 AI056575-05, U19 AI056575] Funding Source: Medline
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. (C) 2008 Elsevier Ltd. All rights reserved.
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