4.8 Article

Mutational spectrum and precision oncology for biliary tract carcinoma

期刊

THERANOSTICS
卷 11, 期 10, 页码 4585-4598

出版社

IVYSPRING INT PUBL
DOI: 10.7150/thno.56539

关键词

biliary tract cancer; precision medicine; targeted therapy; genomic alterations; molecular screening

资金

  1. International Science and Technology Cooperation Projects [2016YFE0107100, 2015DFA30650]
  2. CAMS Innovation Fund for Medical Science (CIFMS) [2017-I2M-4-003]
  3. Beijing Natural Science Foundation [L172055]
  4. National Ten-thousand Talent Program
  5. Beijing Science and Technology Cooperation Special Award
  6. CAMS Initiative for Innovative Medicine [CAMS-2018-I2M-3-001]
  7. National Natural Science Foundation of China [31470069]
  8. Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2017PT32001]
  9. National Science Foundation for Young Scientists of China [81802735]

向作者/读者索取更多资源

The study revealed extensive genomic diversity and heterogeneity among biliary tract carcinoma (BTC) patients, with different gene mutations having varying impacts on patient prognosis. Personalized targeted therapies showed significant efficacy in patients with potentially actionable targets, providing a basis for further clinical trials.
Background: The genomic spectrum of biliary tract carcinoma (BTC) has been characterized and is associated with distinct anatomic and etiologic subtypes, yet limited studies have linked genomic alterations with personalized therapies in BTC patients. Methods: This study analyzed 803 patients with BTC:164 with gallbladder cancer, 475 with intrahepatic cholangiocarcinoma (ICC) and 164 with extrahepatic cholangiocarcinoma. We determined genomic alterations, mutational signatures related to etiology and histopathology and prognostic biomarkers. Personalized targeted therapies for patients harboring potentially actionable targets (PATs) were investigated. Results: The median tumor mutation burden (TMB) was 1.23 Mut/Mb, with 4.1% of patients having hypermutated BTCs. Unlike the results obtained from the Western population, the most frequently altered cancer-related genes in our cohort included TP53 (53%), KRAS (26%), ARID1A (18%), LRP1B (14%) and CDKN2A (14%). Germline mutations occurred mostly in DNA damage repair genes. Notably, 35.8% of the ICCs harbored aristolochic acid related signatures and an elevated TMB. TP53 and KRAS mutations and amplified 7q31.2 were demonstrated to negatively affect patient prognosis. Moreover, 19 genes were proposed to be PATs in BTCs, with 25.4% of patients harboring these PATs. Forty-six patients received PAT-matched targeted therapies, achieving a 26.1% objective response rate; the median progression-free survival (PFS) was 5.0 months, with 56.8% of patients obtaining PFS benefits. Conclusions: Extensive genomic diversity and heterogeneity were observed among BTC patients, with contributions according to potential etiology exposures, anatomical subtypes and clinicopathological characteristics. We also demonstrated that patients with refractory BTCs who have PATs can derive considerable benefit from receiving a matched therapy, initiating further prospective clinical trials guided by molecular profiling among this aggressive cancer.

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