COMPARISON OF PROGNOSIS BETWEEN DIABETIC AND NONDIABETIC PERITONEAL DIALYSIS PATIENTS

Introduction: Diabetes mellitus (DM) nephropathy is one of the common causes of renal failure. It is unknown whether there is a difference between prognosis of DM and non-diabetes mellitus (N-DM) peritoneal dialysis (PD) patients. The aim of the study was to compare prognosis between diabetic and nondiabetic PD patients. Materials and methods: We recruited patients who began PD between January 2010 and January 2018. General demographic data and biochemical indicators were collected. Patients were divided into DM and N-DM groups. All patients were followed up until death, kidney transplantation or September 1, 2019. The technical survival rate and overall survival rate between the two groups were compared. The factors influencing prognosis of PD patients were analyzed. Results: A total of 246 PD patients were enrolled, including 50 DM patients(20.33%) and 196 N-DM patients (79.67%). Compared with the patients in the N-DM group, those in the DM group were older and had better residual renal function (P<0.05). Kaplan-Meier analysis showed that there was no difference in the technical survival rate between the two groups (P=0.479). The overall survival rate of the DM group was lower than that of the N-DM group (P=0.014). Cox regression analysis showed that DM was unrelated to the technical survival rate. Multivariate Cox regression showed that DM was not correlated with overall survival rate after adjusting for age and cardiovascular complications. Older age and presence of cardiovascular complications were independent mortality risk factors in PD patients. Conclusion: Technical survival rate in DM patients was similar to that in N-DM patients. After adjusting for age and cardiovascular complications, DM was also not associated with overall survival rate. Patients with DM can receive PD treatment.

Automated summary

This study compared the prognosis of diabetic and nondiabetic PD patients and found that although the overall survival rate of diabetic patients was lower, the technical survival rate was similar to that of nondiabetic patients. Older age and cardiovascular complications were independent mortality risk factors in PD patients.