期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 1, 页码 241-246出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.10.093
关键词
TACE inhibitor
beta-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in vivo criteria for the program and was selected for further evaluation. (C) 2007 Elsevier Ltd. All rights reserved.
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