期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 23, 页码 6265-6267出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.082
关键词
Carbohydrates; Glycosyl triazoles; Click chemistry; Arabinose; Mycobacteria; Tuberculosis
资金
- EPSRC [D051495/1]
- EPSRC [EP/D051495/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D051495/1] Funding Source: researchfish
A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain. (C) 2008 Elsevier Ltd. All rights reserved.
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