期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 9, 页码 2840-2844出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.03.079
关键词
thiazolidine; Lyp; pTyr mimics; salicylate
资金
- NHGRI NIH HHS [U54 HG003914-02, U54 HG003914, U54 HG003914-01, U54 HG003914-03] Funding Source: Medline
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modi. cation by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency. (c) 2008 Elsevier Ltd. All rights reserved.
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