4.7 Letter

Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection

期刊

EMERGING INFECTIOUS DISEASES
卷 27, 期 2, 页码 660-663

出版社

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2702.203884

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资金

  1. Center for Research on Influenza Pathogenesis - National Institutes of Allergy and Infectious Diseases, National Institutes of Health [HHSN272201400008C]
  2. Research Program on Emerging and Re-emerging Infectious Disease from Japan Agency for Medical Research and Development (AMED) [JP19fk0108113]
  3. Japan Initiative for Global Research Network on Infectious Diseases from AMED [JP19fm0108006]
  4. Japan Program for Infectious Diseases Research and Infrastructure from AMED [JP20wm0125002]
  5. University of Wisconsin K12 Career Development Award from the National Institute of Diabetes and Digestive and Kidney Diseases [K12DK100022]

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It is easily for Severe acute respiratory syndrome coronavirus 2 to transmit between domestic cats. Recovered domestic cats may have some protection against reinfection, but long-term persistence of inflammation and other lung lesions were found after infection despite limited viral replication and absence of clinical symptoms.
Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection might be protected from reinfection. However, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical symptoms and limited viral replication in the lungs.

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