期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 16, 页码 4538-4543出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.042
关键词
spiro-thioxanthene; spiro-xanthene-9 ',2-[1,3.4]thiadiazole; single crystal X-ray structural analysis; anti-inflammatory and analgesic activities
The 1,3-dipolar cycloaddition of nitrile immes to 9H-thioxanthone-9-thione and 9H-xanthone-9-thione afforded novel spiro-thioxanthene-9',2-[1,3,4] thiadiazoles 6a-g and spiro-xanthene-9',2-[1,3,4]thiadiazoles 7a-g in good yields. Some of the newly synthesized compounds were tested for anti-inflammatory and analgesic activities comparable to ibuprofen. Compounds 6a,d,e and 7a,d,e showed significant activity compared to standard drug. The toxicity studies revealed that neither death nor other behavioral or toxicological changes were observed on rats up to a dose as high as 200 mg/kg. (c) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据