期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 3, 页码 954-958出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.12.034
关键词
angiogenesis; inhibitor; alpha-glucosidase; methionine aminopeptidase; aryl-1,2,3-triazole; 1-deoxynojirimycin; bifunctional compound; hybrid
Synthesis of hybrids of 1-deoxynojirimycin (DNJ) and 5-aryl-1,2,3-triazole as potential bifunctional inhibitors of angiogenesis is described. The DNJ component inhibits the biosynthesis of cell surface oligosaccharides necessary for angiogenesis, whereas the aryl-1,2.3-triazole inhibits methionine aminopeptidase II, a target in angiogenesis therapy. One bifunctional compound was a more potent inhibitor of angiogenesis in vitro than DNJ alone or the 5-aryl-1,2,3-triazole alone. (C) 2007 Elsevier Ltd. All rights reserved.
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