2,4(5)-Diarylimidazoles:: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2

A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNa(v)1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Na(v)1.2 currents, emerging as a promising lead compound for further structure-activity relationship studies for the development of novel sodium channel blockers. (c) 2008 Elsevier Ltd. All rights reserved.