期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 17, 页码 4864-4867出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.107
关键词
benzodiazepine binding site; chalcones
资金
- CNRS
- MNERT
- French and Danish ministries
- Carlsberg foundation
The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-mu M range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series. (C) 2008 Elsevier Ltd. All rights reserved.
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