期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 26, 期 20, 页码 5538-5546出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2018.09.033
关键词
Depression; 4-Arylpiperazine; 4-Benzylpiperidine; Naphthyl ether; Serotonin reuptake inhibitor; Norepinephrine reuptake inhibitor; Docking
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2012R1A1A2006613]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF)
- Korean government (MSIT) [NRF-2017M3A9G2077568]
Two series of 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers were designed based on structure-activity relationship (SAR) and docking model of reported monoamine neurotransmitters reuptake inhibitors. The compounds were synthesized in 3-simple steps and their biological activities were evaluated. Several compounds were proven to be potent inhibitors of serotonin and norepinephrine reuptake. Computer docking was performed to study the interaction of the most potent compound 35 with human serotonin transporter. The results of the analyses suggest that 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers might be promising anti-depressants worthy of further studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据