期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 22, 期 2, 页码 842-847出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.12.007
关键词
Apoptosis; Cytotoxicity; Acylated hydroquinones; Anti-lymphoma; Photochemistry
资金
- NIGMS SCORE Grant [1SC3GM10 3713]
- RISE program [NIGMS/NIH 2R25GM069621-10]
- University of Texas at El Paso (University Research Institute Award)
- Research Centers for Minority Institutions Grant from the National Institutes on Minority Health and Health Disparities (NIMHD) a component of NIH [8G12MD007592]
Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death. (C) 2013 Elsevier Ltd. All rights reserved.
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