期刊
ENDOCRINOLOGY
卷 162, 期 7, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/endocr/bqab065
关键词
glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); hormone antagonists; hormone coagonists; exendin 9-39
The incretin effect, mediated by GIP and GLP-1, plays a crucial role in postprandial insulin secretion and glucose tolerance. GIP is the key hormone in healthy individuals, and its loss in type 2 diabetes contributes significantly to impaired postprandial glucose control.
The incretin effect-the amplification of insulin secretion after oral vs intravenous administration of glucose as a mean to improve glucose tolerance-was suspected even before insulin was discovered, and today we know that the effect is due to the secretion of 2 insulinotropic peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). But how important is it? Physiological experiments have shown that, because of the incretin effect, we can ingest increasing amounts of amounts of glucose (carbohydrates) without increasing postprandial glucose excursions, which otherwise might have severe consequences. The mechanism behind this is incretin-stimulated insulin secretion. The availability of antagonists for GLP-1 and most recently also for GIP has made it possible to directly estimate the individual contributions to postprandial insulin secretion of a) glucose itself: 26%; b) GIP: 45%; and c) GLP-1: 29%. Thus, in healthy individuals, GIP is the champion. When the action of both incretins is prevented, glucose tolerance is pathologically impaired. Thus, after 100 years of research, we now know that insulinotropic hormones from the gut are indispensable for normal glucose tolerance. The loss of the incretin effect in type 2 diabetes, therefore, contributes greatly to the impaired postprandial glucose control.
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