期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 22, 期 7, 页码 2005-2032出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.02.017
关键词
Synthesis; New drug molecules; New chemical entities; Medicine; Therapeutic agents
New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011. (C) 2014 Elsevier Ltd. All rights reserved.
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