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Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

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Article Biotechnology & Applied Microbiology

Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

Kie Kyon Huang et al.

Summary: In this study, a comprehensive survey of the transcriptome of gastric cancer was conducted using a combination of long-read and short-read RNA sequencing technologies. The results revealed a large number of novel transcripts, which are more likely to be cell line and subtype specific, expressed at lower levels, with larger number of exons, and longer sequence lengths. The study also identified cancer-associated isoforms and potential changes in coding sequences, providing valuable insight for deeper studies of gastrointestinal malignancies.

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