期刊
NEUROPSYCHIATRIC DISEASE AND TREATMENT
卷 17, 期 -, 页码 2697-2706出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S323127
关键词
Parkinson's disease; mild cognitive impairment; ReHo; fMRI; DMN
资金
- National Natural Science Foundation of China [81771807, 81901729]
- Science and Technology Planning Project of Guangzhou [202002030234]
This study aimed to compare regional homogeneity (ReHo) changes between PD-MCI patients, PD-CN patients, and NC subjects, as well as investigate the relationship between ReHo changes and neuropsychological variation. The results revealed significant ReHo value differences in various brain regions among the three groups, suggesting potential early biomarkers for cognitive impairment in PD.
Purpose: The aim of this study was to compare regional homogeneity (ReHo) changes in Parkinson's disease mild cognitive impairment (PD-MCI) patients with respect to normal controls (NC) and those with cognitively normal PD (PD-CN). Further, the study investigated the relationship between ReHo changes in PD patients and neuropsychological variation. Patients and Methods: Thirty PD-MCI, 19 PD-CN, and 21 NC subjects were enrolled. Resting state functional magnetic resonance imaging data of all subjects were collected, and regional brain activity was measured for ReHo. Analysis of covariance for ReHo was determined between the PD-MCI, PD-CN, and NC groups. Spearman rank correlations were assessed using the ReHo maps and data from the neuropsychological tests. Results: In comparison with NC, PD-CN patients showed significantly higher ReHo values in the right middle frontal gyrus (MFG) and lower ReHo values in the left supramarginal gyrus, bilateral inferior parietal lobule (IPL), and the right postcentral gyrus (PCG). In comparison with PD-CN patients, PD-MCI patients displayed significantly higher ReHo values in the right PCG, left middle occipital gyrus (MOG) and IPL. No significant correlation between ReHo indices and the neuropsychological scales was observed. Conclusion: Our finding revealed that decreases in ReHo in the default mode network (DMN) may appear before PD-related cognitive impairment. In order to preserve executive attention capacity, ReHo in the right MFG in PD patients lacking cognition impairment increased for compensation. PD-MCI showed increased ReHo in the left MOG, which might have been caused by visual and visual-spatial dysfunction, and increased ReHo in the left IPL, which might reflect network disturbance and induce cognition deficits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据