期刊
PAEDIATRICS & CHILD HEALTH
卷 26, 期 4, 页码 228-233出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/pch/pxaa031
关键词
Cannabidiol; Cannabis; Drug-resistant epilepsy; Medicinal marijuana; Scoping review; Tetrahydrocannabinoid
类别
资金
- Evidence to Innovation Pharmacology Group
- BC Children's Hospital Research Institute
The evidence for the efficacy and safety of medicinal cannabis in most pediatric conditions is lacking.
Introduction: The use of medicinal cannabis in the paediatric age group is increasing despite the lack of evidence for its efficacy or safety. Objective: To map the available evidence on the efficacy and safety of medicinal cannabis in children and adolescents. Methods: We conducted a scoping review and searched six electronic databases and grey literature. A study was eligible for inclusion when it investigated the efficacy or safety of medicinal cannabis for any condition, more than half of the participants were 0 to 18 years old, and had any study design except single case reports. Results: We included 36 studies in our final analysis, 32 of which investigated the efficacy or safety of cannabis in treatment-resistant epilepsy. The remaining 4 studies examined patients with cancer, dysautonomia, Epidermolysis Bullosa, and motor disorders. Conclusions: There is a lack of evidence on the efficacy and safety of medicinal cannabis in most paediatric conditions.
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