期刊
CCS CHEMISTRY
卷 3, 期 5, 页码 1336-1349出版社
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.020.202000266
关键词
NIR-II; copper sulfide; alkyl radical; synergistic therapy; imaging
资金
- National Key R&D Program of China [2017YFA0701301]
- National Natural Science Foundation of China [21922406, 21775071, 21632008]
- Natural Science Foundation of Jiangsu Province [BK20190055]
- Fundamental Research Funds for the Central Universities [020514380185]
- Excellent Research Program of Nanjing University [ZYJH004]
This study introduces a novel phototherapy utilizing hybrid copper sulfide nanoparticles loaded with AIBA to induce tumor hyperthermia and cytotoxic alkyl radicals. The therapy demonstrates high photothermal conversion efficiency and low-power density irradiation effectiveness, showing promise for combinational tumor phototherapy involving photothermal therapy, alkyl radical therapy, and chemodynamic therapy.
Near-infrared (NIR)-II light-excitable photonic agents capable of generating tumor hyperthermia and cytotoxic free radicals are promising for synergistic phototherapy of tumors. However, the lack of NIR-II excitable agents makes it challenging to achieve combinational tumor phototherapy. Here, the authors have reported on a tumor-targeting and degradable hybrid copper sulfide (CuS) nanoparticle (AIBA@CuS-FA) via loading a hydrophilic Azo initiator (AIBA) into an amphiphilic lipid-encapsulating CuS nanoparticle. AIBA@CuS-FA shows high photothermal conversion efficiency (PCE approximate to 47.5%) at 1064 nm, enabling heat production to trigger tumor hyperthermia and thermal decomposition of AIBA into cytotoxic free alkyl radicals upon irradiation with a 1064-nm laser under low-power density (0.5 W/cm(2)). Moreover, alkyl radicals can drive degradation of AIBA@CuS-FA and embedded CuS nanodisks, releasing Cu2+ ions that can catalyze a Fenton-like reaction for hydroxyl radical (center dot OH) production to promote tumor therapy. Findings demonstrate promise for combinational photothermal therapy (PTT), oxygen-independent alkyl radical therapy, and chemodynamic therapy (CDT) of tumors.
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