期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 16, 页码 4831-4838出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.03.014
关键词
Imino sugars; Neoglycoconjugates; Bovine viral diarrhea virus; Endoplasmic reticulum; Glucosidases
资金
- ANR program 'Jeunes Chercheuses-Jeunes Chercheurs' [ANR-05-JCJC-0199]
- Glycobiology Institute
Deoxynojirimycin (DNJ) based imino sugars display antiviral activity in the tissue culture surrogate model of Hepatitis C (HCV), bovine viral diarrhoea virus (BVDV), mediated by inhibition of ER alpha-glucosidases. Here, the antiviral activities of neoglycoconjugates derived from deoxynojirimycin, and a novel compound derived from deoxygalactonojirimycin, by click chemistry with functionalised adamantanes are presented. Their antiviral potency, in terms of both viral infectivity and virion secretion, with respect to their effect on alpha-glucosidase inhibition, are reported. The distinct correlation between the ability of long alkyl chain derivatives to inhibit ER alpha-glucosidases and their anti-viral effect is demonstrated. Increasing alkyl linker length between DNJ and triazole groups increases alpha-glucosidase inhibition and reduces the production of viral progeny RNA and the maturation of the envelope polypeptide. Disruption to viral glycoprotein processing, with increased glucosylation on BVDV E2 species, is representative of alpha-glucosidase inhibition, whilst derivatives with longer alkyl linkers also show a further decrease in infectivity of secreted virions, an effect proposed to be distinct from alpha-glucosidase inhibition. (C) 2013 Elsevier Ltd. All rights reserved.
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