期刊
ONCOIMMUNOLOGY
卷 10, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2021.1873585
关键词
B cells; tumor microenvironment; immune checkpoint; melanoma; inflammation
资金
- Swiss Cancer Research Foundation [KFS3971-08-2016]
- Swiss TransMed [KIP 18]
- Cancer Research Institute
- Alfred and Annemarie von Sick
- University of Lausanne
The role of B cells in solid tumor patients is insufficiently understood. Research suggests that B cells may promote tumor growth by producing inflammatory cytokines, affecting treatment response and overall survival. Different subsets of B cells may have varying impacts on tumor development, necessitating further study for identification and characterization.
The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNF alpha and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNF alpha expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.
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