期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 231, 期 1, 页码 31-35出版社
WILEY-BLACKWELL
DOI: 10.1002/jcp.25062
关键词
-
资金
- National Institutes of Health [P01 CA082834, R01 CA139322]
Three-dimensional organization of the chromatin has important roles in transcription, replication, DNA repair, and pathologic events such as translocations. There are two fundamental ways to study higher-order chromatin organization: microscopic and molecular approaches. In this review, we briefly introduce the molecular approaches, focusing on chromosome conformation capture or 3C technology and its derivatives, which can be used to probe chromatin folding at resolutions beyond that provided by microscopy techniques. We further discuss the different types of data generated by the 3C-based methods and how they can be used to answer distinct biological questions. J. Cell. Physiol. 230: 31-35, 2016. (c) 2015 Wiley Periodicals, Inc.
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