期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 7, 页码 2079-2087出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.01.016
关键词
Anti-HIV agents; PD 404182; Photoaffinity labeling; Pyrimidobenzothiazine
资金
- MEXT
- Health and Labor Science Research Grants (Research on HIV/AIDS, Japan)
- JSPS
- Grants-in-Aid for Scientific Research [10J01895, 24791021, 23390025] Funding Source: KAKEN
To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photo-affinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives. In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据