期刊
GUT MICROBES
卷 13, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2021.1897216
关键词
Anorexia nervosa; intestinal microbiota; germ-free; gnotobiotic mice; body weight; adiposity
资金
- National Institute of Mental Health [R01MH105684]
- National Institute of Diabetes and Digestive and Kidney Diseases [T32DK007686, T32DK07737, P30DK034987, P30DK056350]
- NIMH [R01MH120170, R01MH119084, R01MH118278, U01MH109528]
- Brain and Behavior Research Foundation Distinguished Investigator Grant
- Swedish Research Council [Vetenskapsradet538-2013-8864]
- Lundbeck Foundation [R276-2018-4581]
- Forskningsradet for Arbetsliv och Socialvetenskap [538-2013-8864]
Analyses show a significant association between gut microbiota from patients with anorexia nervosa and body weight, fat mass, and cecum weight in colonized germ-free mice, regardless of the donor group, suggesting a strong impact of human fecal microbes on these physiological parameters.
Anorexia nervosa (AN) is a psychiatric disorder that presents with profound weight dysregulation, metabolic disturbances, and an abnormal composition of gut microbial communities. As the intestinal microbiota can influence host metabolism, the impact of enteric microbial communities from patients with AN on host weight and adiposity was investigated. Germ-free (GF) mice were colonized with fecal microbiotas from either patients with AN (n = 4) prior to inpatient treatment (AN T1, n = 50 recipient mice), the same 4 patients following clinical renourishment (AN T2, n = 53 recipient mice), or age- and sex-matched non-AN controls (n = 4 human donors; non-AN, n = 50 recipient mice). Biological and fecal microbiota data were analyzed with linear mixed-effects models. Body weight did not differ significantly between AN recipient mice (T1 and T2) and non-AN recipient mice following 4 weeks of colonization. Enteric microbiotas from recipient mice colonized with AN T1 and AN T2 fecal microbiotas were more similar to each other compared with enteric microbiotas from non-AN recipient mice. Specific bacterial families in the Actinobacteria, Bacteroidetes, and Firmicutes phyla were significantly associated with body weight, fat mass, and cecum weight irrespective of the donor group. These data suggest that body weight, fat mass, and cecum weight of colonized GF mice are associated with human fecal microbes and independent of donor AN status, although additional analyses with larger cohorts are warranted.
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