期刊
EMERGING MICROBES & INFECTIONS
卷 10, 期 1, 页码 1156-1168出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2021.1938241
关键词
SARS-CoV-2; alternate infection; convalescent stage; hACE2 transgenic mice
资金
- National Natural Science Foundation of China [32070923]
- CAMS Initiative for Innovative Medicine [2016I2M-1-014, 2020-I2M-2-014]
Recent studies have shown that mice challenged with H1N1 virus after SARS-CoV-2 infection exhibit enhanced viral shedding and tissue distribution, as well as severe inflammation infiltration and bronchiole disruption in the lungs. Additionally, lymphocyte population showed lower T cell activation levels upon exposure to H1N1 after SARS-CoV-2 infection.
The risk of secondary infection with SARS-CoV-2 and influenza A virus is becoming a practical problem that must be addressed as the flu season merges with the COVID-19 pandemic. As SARS-CoV-2 and influenza A virus have been found in patients, understanding the in vivo characteristics of the secondary infection between these two viruses is a high priority. Here, hACE2 transgenic mice were challenged with the H1N1 virus at a nonlethal dose during the convalescent stage on 7 and 14 days post SARS-CoV-2 infection, and importantly, subsequent H1N1 infection showed enhanced viral shedding and virus tissue distribution. Histopathological observation revealed an extensive pathological change in the lungs related to H1N1 infection in mice recovered from SARS-CoV-2 infection, with severe inflammation infiltration and bronchiole disruption. Moreover, upon H1N1 exposure on 7 and 14 dpi of SARS-CoV-2 infection, the lymphocyte population activated at a lower level with T cell suppressed in both PBMC and lung. These findings will be valuable for evaluating antiviral therapeutics and vaccines as well as guiding public health work.
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