期刊
EMERGING MICROBES & INFECTIONS
卷 10, 期 1, 页码 2173-2182出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2021.1997074
关键词
SARS-CoV-2; variants of concern (VOC); African green monkey; transmission; virulence
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
The study compared the infection of two different SARS-CoV-2 variants in African green monkeys and found that the B.1.1.7 variant had higher levels of replication and shedding in the respiratory tract, while the D614G variant had higher levels of replication and shedding in the gastrointestinal tract.
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases.
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