Correlation of humoral immune responses to different SARS-CoV-2 antigens with virus neutralizing antibodies and symptomatic severity in a German COVID-19 cohort

Article Immunology

Role of Immunoglobulin M and A Antibodies in the Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2

Jeromine Klingler et al.

Summary: The study found that spike- and RBD-specific IgM, IgG1, and IgA1 were produced by all or nearly all individuals in convalescent plasma, with these immunoglobulins playing critical roles in neutralizing the virus.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline

Shelly Bolotin et al.

Summary: The study revealed that as time passed, the concentration of antibodies in SARS-CoV-2 positive specimens decreased, while the concentration in negative specimens increased. The association between the two tests also decreased over time, indicating a decline in anti-nucleocapsid antibodies.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Cell Biology

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin et al.

Summary: The study found that humoral immune responses to SARS-CoV-2 infection are dominated by IgA antibodies, with specific IgA plasmablasts rapidly expanding shortly after symptom onset and peaking in the third week of the disease. Virus-specific antibody responses include IgG, IgM, and IgA, with IgA playing a greater role in virus neutralization compared to IgG.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Biochemical Research Methods

Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples

Livia Mazzini et al.

Summary: This study aimed to detect SARS-CoV-2-specific antibodies in human serum samples to predict population immunity, identify potential infectious individuals, and confirm the significant neutralizing effect of antibodies against the receptor-binding domain of the virus spike protein.

JOURNAL OF IMMUNOLOGICAL METHODS (2021)

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Article Cell Biology

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

Romain Gasser et al.

Summary: Depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This finding may have implications for designing more effective antibody-based COVID-19 therapies and explaining the increased susceptibility of autoimmune patients receiving therapies that inhibit the production of immunoglobulin M (IgM).

CELL REPORTS (2021)

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Article Infectious Diseases

Evaluation of a commercially-available surrogate virus neutralization test for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Emelissa J. Valcourt et al.

Summary: The study evaluated the sensitivity, specificity, and cross-reactivity of sVNT compared with PRNT for SARS-CoV-2 neutralizing antibodies, finding sVNT to be a high-throughput screening tool for evaluation prior to confirmatory PRNT testing.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2021)

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Article Immunology

Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods

Berislav Bosnjak et al.

Summary: The study found that COVID-19 convalescent patients have neutralizing antibodies in their serum that can effectively block the entry of SARS-CoV-2 virus. The levels of these neutralizing antibodies are correlated with the duration and severity of clinical symptoms, but not with age. The sVNT test is simpler, faster, and more cost-effective compared to the pVNT test, making it valuable for assessing the prevalence of neutralizing antibodies and selecting potential plasma donors for successful passive antibody therapy.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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