期刊
EMERGING MICROBES & INFECTIONS
卷 10, 期 1, 页码 1088-1096出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2021.1934557
关键词
Candida auris; whole-genome resequencing; South African clade; epidemiology; ERG11
资金
- National Key Specialist Construction Project for Clinical Laboratory Medicine
- Laboratory medicine innovation unit, Chinese Academy of Medical Sciences [2019RU017]
This study investigated the microbiological characteristics and antifungal susceptibility of Candida auris isolates collected in Shenyang from 2016 to 2018. The findings revealed that the isolates mainly originated from ICU wards and showed fluconazole resistance due to mutations in the drug resistance gene ERG11. The study provides important insights into the origin of C. auris in Shenyang and contributes to the understanding of its epidemiological characteristics worldwide.
Candida auris is an emerging pathogenic fungal species found worldwide. Since April 2016, C. auris colonization/infection cases have been found in a general hospital in Shenyang, China. The genome-based phylogenetic studies of these isolates remain undefined. In the current study, the microbiological characteristics and antifungal susceptibility of these C. auris isolates, which were collected in Shenyang during the three-year period (2016-2018), were investigated. Whole-genome sequencing was applied to investigate the genetic variation and molecular epidemiological characteristics. A total of 93 C. auris isolates, including 92 clinical isolates and 1 environmental screening isolate were identified. Among the investigated wards, the C. auris cases were the most prevalent (97.4%, 37/38) in four intensive care units (ICUs). The Shenyang isolates carrying the VF125AL mutation in the key drug-resistance gene ERG11 were mainly fluconazole resistant and formed a distinct subclade under the South African clade according to the phylogenetic and population structural analyses. In addition, the Shenyang subclade was found to be closely related to the British subclade in the aspect of genetic distance. As a conclusion, this study provides an important clue for revealing the origin of C. auris found in Shenyang and could also contribute to improve the understanding of the epidemiological characteristics of C. auris worldwide.
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