期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 11, 页码 2999-3009出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.03.071
关键词
Quinone; Benzofuran; Benzothiophene; Indazole; Quinone reductase; NQO1
资金
- FORCE Cancer Charity
- Cancer Research Campaign
- NIH [P20RR017670]
A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione. (C) 2013 Elsevier Ltd. All rights reserved.
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