期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 19, 页码 6011-6014出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.07.040
关键词
DNA; Perylenediimide; Mismatch base pair; Fluorescence; Excimer
资金
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [25620136, 23750198] Funding Source: KAKEN
Small ligand molecules, which can recognize thermodynamically unstable site within DNA, such as mismatch base pair, abasic site, and single-bulge, have attracted much attention because of their potential diagnostics and biological applications. In this paper, we describe the binding of cationic perylenediimide (cPDI) molecules to thymine-containing mismatch base pair in DNA and the formation of cPDI dimer at the mismatch site. The cPDI dimer exhibits a characteristic excimer emission at 650 nm. For T/T mismatch containing DNA, the switching behavior from the PDI dimer (650 nm) to the monomer (550 nm) emission in specific response to Hg2+ ion was observed. (c) 2013 Elsevier Ltd. All rights reserved.
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