期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 15, 页码 4628-4633出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.05.022
关键词
Cellular slime molds; Dictyostelium discoideum; Dibenzofuran; Stalk cell differentiation; Gene expression
资金
- Ministry of Education, Science, Sports and Culture of Japan [23710247, 24590110]
- SUNBOR GRANT from the Suntory Institute for Bioorganic Research
- Grants-in-Aid for Scientific Research [23710247, 24590110] Funding Source: KAKEN
Cellular slime molds are expected to have the huge potential for producing secondary metabolites including polyketides, and we have studied the diversity of secondary metabolites of cellular slime molds for their potential utilization as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium filamentosum, we obtained new chlorinated benzofurans Pf-1 (4) and Pf-2 (5) which display multiple biological activities; these include stalk cell differentiation-inducing activity in the well-studied cellular slime mold, Dictyostelium discoideum, and inhibitory activities on cell proliferation in mammalian cells and gene expression in Drosophila melanogaster. (C) 2013 Elsevier Ltd. All rights reserved.
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